I’ve been using Wire for year and a half now. Though with only few people, as all the others use WhatsApp and/or Viber. I stopped using Viber some time ago, and hope Facebook will introduce ads to Whatsapp, so I’ll have easy explanation why I need to delete WA.
There are some issues (with notifications) recently, but I hope it’ll be resolved soon. In my opinion, it is the best overall IM/VoIP software at the moment, though I would be happy to use any other (Signal, Riot, XMPP w. OMEMO, Keybase…) if any of my friends or family members were willing to ditch Whatsapp/Viber.
The only concern regarding Wire is - it might not be possible to use it on Librem5, or Pinephone or something similar, if I switch from Android.
Though it can’t be used this way as IM on mobile devices. Still, I hope it might be in some way usable on other devices (linux-based mobile OS). I actually prefer to use PC for IM, no matter what software it is. So as long as I can read messages on the phone, I’m fine with it 